A TOOLBOX OF AMINO ACIDS FOR OUT-OF-THE-BOX mAb SEPARATIONS
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چکیده
Size exclusion chromatography (SEC) is well established for mAb aggregate analysis. As the technique has been used since the early days of mAb development for pharmaceutical purposes, various method improvements have evolved. For instance, the benefits of arginine on analytical SEC of mAb aggregate samples are well-known. Herein, we present how SEC of mAb aggregate samples may take advantage of other amino acid additives in the mobile phase.
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